Endocrine Abstracts

Introduction: Prolactin (PRL) is a hormone utilized at both endocrine and autocrine levels. PRL regulates cyclin D1 expression through JAK2-mediated transcriptional activation of cyclin D1 promoter. Serine–threonine kinase PAK1 is also implicated in regulation of cyclin D1 gene expression. We previously showed that PAK1 binds to and is Tyr phosphorylated by JAK2. Herein we linked PRL and PAK1 as JAK2 substrate to stimulation of cyclin D1 promoter activity.<p class="ab...